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Antioxidant and anti-osteoporotic effects of anthraquinones and related constituents from the aqueous dissolved Aloe exudates

Author:
Sun, Ya Nan, Li, Wei, Lee, Sang Hyun, Jang, Hae Dong, Ma, Jin Yeul, Kim, Young Ho
Source:
Natural product research 2017 v.31 no.23 pp. 2810-2813
ISSN:
1478-6427
Subject:
Aloe, acid phosphatase, anthraquinones, antioxidant activity, antioxidants, phytopharmaceuticals, transcription factor NF-kappa B
Abstract:
In this study, 25 known anthraquinones and related compounds were isolated from aqueous dissolved Aloe exudates. The antioxidant and anti-osteoporotic activities of the isolated compounds were then investigated. Compounds 8 , 11 , 20 , and 23 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays at a concentration of 10.0 μM. Additionally, compounds 7 , 9 , 15–16 , 18 , 21–22 and 24–25 showed potent peroxyl radical-scavenging activities with values ranging from 5.28 to 14.60 at 10.0 μM. Moreover, compounds 8 , 11 , 15 , 20 and 22 exhibited significantly suppressed tartrate-resistant acid phosphatase (TRAP) activity in nuclear factor-κB ligand-activated osteoclastic RAW 264.7 cells, with values of 125.67, 118.54, 127.64, 125.82 and 124.98%, respectively. These results indicate that Aloe is an excellent source of antioxidant and anti-osteoporotic phytochemicals.
Agid:
5865395