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Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida

Author:
Zhu, Jian-Yong, Zhang, Chun-Yang, Dai, Jing-Jing, Rahman, Khalid, Zhang, Hong
Source:
Natural product research 2017 v.31 no.23 pp. 2753-2758
ISSN:
1478-6427
Subject:
Jatropha, antioxidant activity, curcumin, diterpenoids, drug therapy, enzyme inhibition, inhibitory concentration 50, neoplasms, spectral analysis, thioredoxins
Abstract:
Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1 – 9), including a new jatromulone A, four podocarpane diterpenoids (2 – 5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions. Compounds 6 and 7 exhibited stronger activity (IC ₅₀: 23.4 and 10.6 μM, respectively) than the positive control, curcumin (IC ₅₀ = 25.0 μM). Compounds 2 – 9 were isolated from J. multifida for the first time.
Agid:
5865397