PubAg

Main content area

New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity

Author:
Li, Jia-Lin, Li, Na, Xing, Shan-Shan, Zhang, Nan, Li, Ban-Ban, Chen, Jian-Guang, Ahn, Jong-Seog, Cui, Long
Source:
Archives of pharmacal research 2017 v.40 no.11 pp. 1265-1270
ISSN:
0253-6269
Subject:
Eleutherococcus senticosus, inhibitory concentration 50, protein-tyrosine-phosphatase, spectroscopy
Abstract:
New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC₅₀ value 15.2 ± 1.4 µM.
Agid:
5866781