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Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus

Author:
Li, Ban-Ban, Li, Jia-Lin, Li, Na, Qi, Shi-Zhou, Lee, Hyun-Sun, Zhang, Le, Xing, Shan-Shan, Tuo, Zhen-Dong, Cui, Long
Source:
Archives of pharmacal research 2017 v.40 no.11 pp. 1271-1277
ISSN:
0253-6269
Subject:
Eleutherococcus senticosus, diacylglycerol acyltransferase, inhibitory concentration 50, lignans, spectral analysis, stems
Abstract:
Two new furofuran lignans were isolated from the stems of Acanthopanax senticosus, along with seven known compounds. Their structures were all determined by spectroscopic analyses and chemical methods. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Compounds 1 and 2 were found to exhibit selective inhibitory activity on DGAT1 with IC₅₀ values 89.5 ± 1.5 and 57.5 ± 1.3 µM, respectively.
Agid:
5866785