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Two New Xanthones From Swertia atroviolacea and Their Anti-5α-Reductase Activity

Author:
Xing, Huan-huan, Xiang, Neng-Jun, Liu, Li-Xuang, Yang, Guo-Rong, Shen, Yan-Fei, Yang, Yan, Zhou, Ling, Ma, Hang-Ying, Zhou, Min, Wu, Hai-Yan, Li, Gan-Peng, Hu, Qiu-Fen
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1052-1055
ISSN:
0009-3130
Subject:
Swertia, enzyme activity, metabolites, spectral analysis, xanthones
Abstract:
Two new xanthones, atroxanthones A and B (1 and 2), together with four known xanthones (3–6), were isolated from the whole herb of Swertia atroviolacea. The structures of the metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 had weak activity with reductase inhibitions of 52.3 ± 2.5% and 42.9 ± 2.8%, respectively.
Agid:
5867253