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Synthesis and Antifungal Activity of Cuminic Acid Derivatives

Author:
Yang, Jian, Gao, Yang, Liu, Hui, Tang, Xiaorong
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1112-1116
ISSN:
0009-3130
Subject:
Bipolaris maydis, Botrytis cinerea, Coniothyrium, Fusarium graminearum, Sclerotinia sclerotiorum, Thanatephorus cucumeris, X-ray diffraction, antifungal properties, carbendazim, crystal structure, plant pathogenic fungi
Abstract:
A series of benzamide derivatives (compounds 1–29) was synthesized based on the lead compound cuminic acid. The crystal structure of compound 11 was characterized by single crystal X-ray diffraction. The antifungal activity of the synthesized compounds was determined against seven plant pathogenic fungi, namely Rhizoctonia solani, Gibberella zeae, Helminthosporium maydis, Sclerotinia sclerotiorum, Botrytis cinerea, Coniothyrium diplodiella, and Coniothyrium lagenarium. Preliminary results indicated that most of them revealed significant antifungal activity. Among them, compound 22 showed the strongest activity and possessed better antifungal activity against H. maydis, S. sclerotiorum, and B. cinerea than carbendazim.
Agid:
5867256