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New Triterpenoids from the Leaves of Alafia barteri

Author:
Hamid, AbdulmumeenA., Aiyelaagbe, OlapejuO., Negi, ArvindS., Luqman, Suaib, Kaneez, Fatima
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1075-1079
ISSN:
0009-3130
Subject:
Apocynaceae, acetates, cytotoxicity, inhibitory concentration 50, leaves, lupane, mass spectrometry, neoplasm cells, nuclear magnetic resonance spectroscopy, stigmasterol, viability
Abstract:
A new oleanane derivative, 3β-acetyloleana-5,12-dien-2,23-diol (1), and a new lupane compound, lup-11,20(29)-dien-3 β,28-diol (2), together with eight known compounds, oleana-5,12-dien-3β-yl acetate (3), lup-5,20(29)-dien-3 β -yl acetate (4), 18-methylethylnonadecan-19-oic-9-enoate (6), octadecane (5), cis-pentadec-7-enoic acid (7), cis-tetradec-7,10-dienoic acid (8), cholest-4-en-3-one (9), and stigmasterol (10), were isolated from the leaves of Alafia barteri. Their structures were elucidated by IR, 1D and 2D NMR, and mass spectroscopy. Compounds 7 and 8 exhibited cytotoxic activities against K562, WRL, and MCF-7 tumor cell lines with IC₅₀ in the range of 8.80 to 37.10 μg/mL, while compounds 2 and 9 suppressed the viability of K562 cells with IC₅₀ of 120.2 and 14.48 μg/mL. Compounds 1, 3, and 4 showed low cytotoxic properties on the tested cell lines.
Agid:
5867257