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Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties
- Ponomarev, K.Yu., Morozova, E.A., Suslov, E.V., Korchagina, D.V., Tolstikova, T.G., Volcho, K.P., Salakhutdinov, N.F.
- Chemistry of natural compounds 2017 v.53 no.6 pp. 1131-1136
- aldehydes, analgesic effect, analgesics, moieties, monoterpenoids, structure-activity relationships
- A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.