U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.


Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Main content area

Two New Alkaloids from the Seeds of Cassia alata and Their Anti-Tobacco Mosaic Virus Activity

Yan Yang, Shan-Zhai Shang, Wei Zhao, Huan-huan Xing, Hang-Ying Ma, Ling Zhou, Min Zhou, Yan-Qing Ye, Hai-Yan Wu, Gang Du, Dong-Lai Zhu, Qiu-Fen Hu
Chemistry of natural compounds 2017 v.53 no.6 pp. 1127-1130
Senna alata, alkaloids, antiviral properties, chemical structure, nuclear magnetic resonance spectroscopy, seed extracts, seeds, spectral analysis, viruses
Two new alkaloids, 3-(hydroxymethyl)-6,9-dimethyl-7H-benzo[de]quinolin-7-one (1) and 3-(hydroxymethyl)-8-methoxy-6,9-dimethyl-7H-benzo[de]quinolin-7-one (2), together with two known alkaloids (3 and 4) were isolated from the seeds of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results revealed that compounds 1–4 have potential anti-TMV activity with inhibition rates of 29.2, 38.5, 24.2, and 28.8% at the concentration of 20 μM, respectively. The inhibition rates of 1 and 2 are higher than that of the postive control.