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The Alkaloidal Constituents of Cephalotaxus mannii Collected in Lam Dong Province, Vietnam
- Van Loc, Tran, Lieu, NguyenThi, Thao, TranThi Phuong, Luu, NguyenThi, Anh, HoNgoc, Ha, LeThi Thu, Van Chien, Tran, Ninh, PhamThi, Phong, DinhThi, Van Sung, Tran
- Chemistry of natural compounds 2017 v.53 no.6 pp. 1122-1126
- Cephalotaxus, Fourier transform infrared spectroscopy, alkaloids, electrospray ionization mass spectrometry, isomers, nuclear magnetic resonance spectroscopy, Vietnam
- Eight alkaloidal constituents have been isolated and structurally elucidated from Cephalotaxus mannii Hook. f. collected from the highland Lam Dong Province, Vietnam. They are: cephalotaxine (1), isoharringtonine (2), norisoharringtonine (3), desoxyharringtonine (4), nordesoxyharringtonine (5), cephalotaxine 𝛽 -N-oxide (6), 3-epi-schellhammericine (7), and an isomer of 3-epi-schellhammericine (8). Among them, norisoharringtonine (3) is a new compound, while the other compounds are isolated from C. mannii for the first time. The structures of these constituents were determined by spectroscopic methods such as FTIR, ESI-MS, HR-ESI-MS, and NMR (1D, 2D) and by comparison with published data.