Reaction of Halogenated Uracils with KI
- Source:
- Chemistry of natural compounds 2017 v.53 no.6 pp. 1140-1143
- ISSN:
- 0009-3130
- Subject:
- chemical reactions, chemical structure, methanol, sulfuric acid
- Abstract:
- Treatment of 5-iodo-1,3,6-trimethyluracil or 5-bromo-1,3,6-trimethyluracil with H₂SO₄ (5%) in the presence of an excess of KI at 80°C for 5 h produced 1,3,6-trimethyluracil as the only product. Analogous treatment of N-bromo-6-iodomethyluracil gave a mixture with 5-bromo-6-iodomethyluracil as the main constituent. The reaction with an excess of KI in MeOH at 50°C formed 5-bromo-6-hydroxymethyluracil, N(1)-iodo-5-bromo-6-hydroxymethyluracil, N(3)-iodo-5-bromo-6-iodomethyluracil, and 5-bromo-6-iodomethyluracil depending on the reaction time.
- Agid:
- 5867272
- https://doi.org/10.1007/s10600-017-2218-6