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First synthetic approach towards K-259-2, a unique calmodulin antagonist
- Basak, Shyam, Mandal, Smita, Mal, Dipakranjan
- Tetrahedron 2017
- antagonists, anthraquinones, calmodulin, chemical reactions, chemical structure, regioselectivity
- K-259-2, a unique calmodulin antagonist, is an allyl chain containing anthraquinone natural product. A regiospecific synthetic approach towards K-259-2 is herein represented. The study also showcases a protocol for synthesizing heavily substituted bromo naphthoate which was found to be suitable for fabricating the K-259-2 motif.