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More than a Tad: spatiotemporal control of Caulobacter pili
- Mignolet, Johann, Panis, Gaël, Viollier, Patrick H
- Current opinion in microbiology 2018 v.42 pp. 79-86
- Caulobacter crescentus, DNA, Myxococcus, Neisseria, Pseudomonas, adhesion, cell cycle, fimbriae, genetic analysis, neonates, pathogens, protein transport, secretion, symbionts
- The Type IV pilus (T4P) is a powerful and sophisticated bacterial nanomachine involved in numerous cellular processes, including adhesion, DNA uptake and motility. Aside from the well-described subtype T4aP of the Gram-negative genera, including Myxococcus, Pseudomonas and Neisseria, the Tad (tight adherence) pilus secretion system re-shuffles homologous parts from other secretion systems along with uncharacterized components into a new type of protein translocation apparatus. A representative of the Tad apparatus, the Caulobacter crescentus pilus assembly (Cpa) machine is built exclusively at the newborn cell pole once per cell cycle. Recent comprehensive genetic analyses unearthed a myriad of spatiotemporal determinants acting on the Tad/Cpa system, many of which are conserved in other α-proteobacteria, including obligate intracellular pathogens and symbionts.