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Using millet as substrate for efficient production of monacolin K by solid-state fermentation of Monascus ruber
- Zhang, Bo-Bo, Xing, Hong-Bo, Jiang, Bing-Jie, Chen, Lei, Xu, Gan-Rong, Jiang, Yun, Zhang, Da-Yong
- Journal of bioscience and bioengineering 2018 v.125 no.3 pp. 333-338
- Monascus ruber, barley, carbon, corn, inoculum, lovastatin, millets, nitrogen, raw materials, red yeast rice, rice, solid state fermentation, water content, wheat
- In this study, various grains such as rice, millet, corn, barley and wheat were used as raw materials for monacolin K production by solid-state fermentation of Monascus ruber. Among these substrates, millet was found to be the best one for monacolin K production, by which the yield reached 7.12 mg/g. For enhanced monacolin K production, the effects of fermentation time, charge amount, initial moisture content and inoculum volume were systematically investigated in the solid-state fermentation of M. ruber. Moreover, complementary carbon source and nitrogen source were added for further improving the production of monacolin K. Results showed that the maximum production of monacolin K (19.81 mg/g) could be obtained at the optimal conditions. Compared with the traditional red mold rice, using millet as substrate is promising for high production of monacolin K in the solid-state fermentation of M. ruber.