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Using millet as substrate for efficient production of monacolin K by solid-state fermentation of Monascus ruber

Zhang, Bo-Bo, Xing, Hong-Bo, Jiang, Bing-Jie, Chen, Lei, Xu, Gan-Rong, Jiang, Yun, Zhang, Da-Yong
Journal of bioscience and bioengineering 2018 v.125 no.3 pp. 333-338
Monascus ruber, barley, carbon, corn, inoculum, lovastatin, millets, nitrogen, raw materials, red yeast rice, rice, solid state fermentation, water content, wheat
In this study, various grains such as rice, millet, corn, barley and wheat were used as raw materials for monacolin K production by solid-state fermentation of Monascus ruber. Among these substrates, millet was found to be the best one for monacolin K production, by which the yield reached 7.12 mg/g. For enhanced monacolin K production, the effects of fermentation time, charge amount, initial moisture content and inoculum volume were systematically investigated in the solid-state fermentation of M. ruber. Moreover, complementary carbon source and nitrogen source were added for further improving the production of monacolin K. Results showed that the maximum production of monacolin K (19.81 mg/g) could be obtained at the optimal conditions. Compared with the traditional red mold rice, using millet as substrate is promising for high production of monacolin K in the solid-state fermentation of M. ruber.