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Four new sesquiterpenoids from Dendranthema morifolium (Ramat.) kitam flowers

Author:
Chen, Wenjing, Zeng, Mengnan, Li, Meng, Li, Fang, Zhao, Xuan, Fan, Hui, Zheng, Xiaoke, Feng, Weisheng
Source:
Phytochemistry letters 2018 v.23 pp. 52-56
ISSN:
1874-3900
Subject:
Chrysanthemum morifolium, acetone, anti-inflammatory activity, ethyl acetate, flowers, inflammation, lipopolysaccharides, nuclear magnetic resonance spectroscopy, sesquiterpenoids
Abstract:
Four new sesquiterpenoids, chrysanthguaianolactones C-F (1–4), together with four known sesquiterpenoids (5–8), including 3α,4α,10β-trihydroxy- 8α-acetoxyguai-1,11(13)-dien-6α,12-olide (5), 3α,4α,10β-trihydroxy-8α-acetoxy −11βH-guai-1-en-12,6α-olide (6), 8α-(angelyloxy)-3β,4β-dihydroxy-5αH,6βH,7αH, 11αH-guai-1(10)-en-12,6-olide (7) and 3β,4α-dihydroxy-8α-angelyloxy-1(10),11(13) −dien-6α,12-olide (8) were obtained from an ethyl acetate fraction, which was yielded from an acetone extract of Dendranthema morifolium (Ramat.) kitam. Their structures were determined with extensive spectroscopic (UV, IR, HR-ESI–MS, and 1D and 2D NMR) analyses. In addition, compounds 1–8 were evaluated for their anti-inflammatory effects on H9c2 cardiocytes impaired by lipopolysaccharide (LPS). Among them, compound 2 and compounds 5–8 exhibited anti-inflammatory effects against LPS-induced inflammation.
Agid:
5871039