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Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway

Author:
Su, Li‐De, Zhang, Qiao‐Ling, Lu, Zhiqiang
Source:
Insect science 2017 v.24 no.1 pp. 17-26
ISSN:
1672-9609
Subject:
Pseudomonas aeruginosa, Staphylococcus aureus, bacteria, bacterial infections, hemolymph, hydrogen peroxide, insect larvae, mitogen-activated protein kinase, oxidation, oxidative stress, silkworms, transcription (genetics), viability
Abstract:
Bacterial infection causes enhanced reactive oxygen species (ROS) levels in insects. Oxidation resistance 1 (OXR1) plays an antioxidant role in eukaryotic organisms, including insects. In this report, we demonstrated that Pseudomonas aeruginosa and Staphylococcus aureus infection and hydrogen peroxide (H₂O₂) injection induced the expression of specific transcriptional isoforms of OXR1 in larval silkworms. We further showed that a Jun kinase (JNK) pathway inhibitor, SP600125, down‐regulated expression of OXR1 during infection, leading to elevated H₂O₂ levels in the hemolymph, resulting in lower viability of the injected bacteria inside the silkworm larvae. Our study suggests that OXR1 participates in protecting larval silkworms from oxidative stress and bacterial infection through the JNK pathway.
Agid:
5882111