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A return to the pore – dissecting Bacillus thuringiensis toxin mode of action via voltage clamp experiments
- Heckel, David G.
- The FEBS journal 2016 v.283 no.24 pp. 4458-4461
- Bacillus thuringiensis, electric power, evolution, mechanism of action, plant pests, plant protection, toxins
- Pore‐forming toxins from Bacillus thuringiensis are increasingly used in crop protection, but evolution of resistance in crop pests threatens their continued deployment. A study by Tanaka et al. shows how voltage clamp experiments that quantify pore formation can be used to dissect toxin mode of action, thereby revealing unexpected complexities that could be exploited to counter resistance.