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Nuclear transplantation, the conservation of the genome, and prospects for cell replacement

Author:
Gurdon, J. B.
Source:
The FEBS journal 2017 v.284 no.2 pp. 211-217
ISSN:
1742-464X
Subject:
Xenopus, amphibians, cell differentiation, eggs, genome, nuclear transplantation, totipotency
Abstract:
Initial nuclear transplantation experiments in Xenopus eggs provided the first evidence for the conservation of the genome after cellular differentiation. This Discovery‐in‐Context Review recounts the early experiments that led to successful nuclear transfer in amphibians and the establishment of totipotency of a differentiated cell and shows how these discoveries paved the way for similar cloning experiments in other organisms.
Agid:
5882406