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Biosynthesis and regulation of cyanogenic glycoside production in forage plants

Author:
Sun, Zhanmin, Zhang, Kaixuan, Chen, Cheng, Wu, Yanmin, Tang, Yixiong, Georgiev, MilenI., Zhang, Xinquan, Lin, Min, Zhou, Meiliang
Source:
Applied microbiology and biotechnology 2018 v.102 no.1 pp. 9-16
ISSN:
0175-7598
Subject:
Lotus, Sorghum (Poaceae), Trifolium, animals, biosynthesis, cyanogenesis, cyanogenic glycosides, economic impact, food safety, hydrogen cyanide, plant development, secondary metabolites, toxicity
Abstract:
The natural products cyanogenic glycosides (CNglcs) are present in various forage plant species including Sorghum spp., Trifolium spp., and Lotus spp. The release of toxic hydrogen cyanide (HCN) from endogenous CNglcs, which is known as cyanogenesis, leads to a serious problem for animal consumption while as defensive secondary metabolites, CNglcs play multiple roles in plant development and responses to adverse environment. Therefore, it is highly important to fully uncover the molecular mechanisms of CNglc biosynthesis and regulation to manipulate the contents of CNglcs in forage plants for fine-tuning the balance between defensive responses and food safety. This review summarizes recent studies on the production, function, polymorphism, and regulation of CNglcs in forage plants, aiming to provide updated knowledge on the ways to manipulate CNglcs for further beneficial economic effects.