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Analysis of various effects of abamectin on erythrocyte morphology in Japanese quails (Coturnix japonica)

Author:
de Faria, DeniseBraga Gomes, Montalvão, MateusFlores, de Souza, JoyceMoreira, de Oliveira Mendes, Bruna, Malafaia, Guilherme, Rodrigues, AlineSueli de Lima
Source:
Environmental science and pollution research international 2018 v.25 no.3 pp. 2450-2456
ISSN:
0944-1344
Subject:
Coturnix japonica, abamectin, avifauna, cytotoxicity, dose response, drinking water, ecosystems, erythrocytes, females, invertebrates, lethal dose 50, micronucleus tests, models, pesticides, quails
Abstract:
Although previous studies have already confirmed the toxicological potential of abamectin (ABA) in different experimental models (from invertebrates to vertebrates), almost nothing is known about the impacts the exposure to this pesticide can cause on birds. Thus, the aim of our study is to investigate the cytotoxic effects on the erythrocytes of female Japanese quails (Coturnix japonica) exposed to low abamectin concentrations. In order to do so, three experimental groups were proposed: “control,” composed of quails exposed to abamectin-free drinking water; “ABA 1% median lethal dose (LD₅₀),” comprising birds exposed to water containing 15.5 mg a.i./L of abamectin (via commercial formulation Kraft® 36EC), and “ABA 10% LD₅₀,” composed by birds exposed to water containing 155.0 mg a.i./L of abamectin. The micronucleus test and the tests applied to other nuclear abnormalities in the peripheral blood of birds were conducted 40 days after exposure. Our study revealed significant physical abnormalities in nuclear shapes (erythrocytes with asymmetric constriction nuclei, notched nuclei, indented and moved nucleus) of those birds exposed to higher abamectin levels. When all nuclear abnormalities were tallied, a significant dose-dependent trend was noted. Therefore, our study presents initial imprints on determination of abamectin-mediated cellular toxicity in avifauna which can be instrumental in checking polluted ecosystems.
Agid:
5889682