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Beneficial effects of an investigational wristband containing Synsepalum dulcificum (miracle fruit) seed oil on the performance of hand and finger motor skills in healthy subjects: A randomized controlled preliminary study

Gorin, Steven, Wakeford, Charles, Zhang, Guodong, Sukamtoh, Elvira, Matteliano, Charles Joseph, Finch, Alfred Earl
Phytotherapy research 2018 v.32 no.2 pp. 321-332
Synsepalum dulcificum, musculoskeletal system, nutrients, phytopharmaceuticals, questionnaires, seed oils
Miracle fruit (Synsepalum dulcificum) seed oil (MFSO) contains phytochemicals and nutrients reported to affect musculoskeletal performance. The purpose of this study was to assess the safety and efficacy of a compression wristband containing MFSO on its ability to measurably improve the hand and finger motor skills of participants. Healthy right‐handed participants (n = 38) were randomized in this double‐blind, placebo‐controlled study of MFSO and vehicle wristbands. Subjects wore the wristband on their left hand 4–6 weeks and then only on their right hand 2–4 weeks; the contralateral untreated hand served as an additional control. Twelve hand/finger motor skills were measured using quantitative bio‐instrumentation tests, and subject self‐assessment questionnaires were conducted. With each hand, in 9/12 tests, the MFSO group showed a clinically meaningful average improvement compared with an average worsening in the vehicle group. Statistical superiority to the control treatment group was exhibited in 9/12 tests for each hand (p < .01). After discontinuing the MFSO wristband on the left hand, test values regressed toward baseline levels. Subjects favored the MFSO wristband over the control, rating it as effective in improving their motor skills. Use of the MFSO wristband may improve an individual's manual dexterity skills and ability to maintain this performance.