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Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats

Zanchet, Barbara, Gomes, Denise B., Corralo, Vanessa S., Diel, Kriptsan A.P., Schönell, Amanda P., Faust, Caroline, Nicola, Patrícia, Muller, Liz G., Zanatta, Ana P., Wildner, Silvana M., Bevilaqua, Fernanda, Chitolina, Rafael, Sachett, Adrieli, Zanatta, Leila, Duarte, Marta M.M.F., Conterato, Greicy M.M., Rocha, Claudia Q., Peretti, Camile, Brumelhaus, Tatiane, Alves, Nayara S., Menegatt, Jean C.O., Conte, Fernanda, Serena, Guilherme, Ramos, Adriano T., Zimermann, Francielli C., Junior, Walter A. Roman
Revista Brasileira de Farmacognosia 2018 v.28 no.1 pp. 80-91
Celtis iguanaea, alpha-glucosidase, antioxidant activity, antioxidants, blood serum, cardiovascular diseases, diabetes mellitus, diet, enzyme activity, flavonoids, glucose, glycemic effect, glycogen, histopathology, hydroxymethylglutaryl-CoA reductases, hypercholesterolemia, interferon-gamma, interleukin-1, liver, low density lipoprotein cholesterol, metabolism, muscles, rats, sucrose alpha-glucosidase, thiobarbituric acid-reactive substances, thiols, tumor necrosis factor-alpha
Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with C. iguanaea extract (C-150, CI-300, or CI-600mg/kg) or simvastatin (4mg/kg) (n=6) once a day (30 days) with a hypercholesterolemic diet. A control group (C) was given saline. C. iguanaea extract showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, interleukin-1 and 6, TNF-α and IFN-γ when compared to group C (p<0.001). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI-600), maltase (CI-150, CI-300), and an increase in muscle glycogen levels (CI-300). Antioxidant effects were observed in plasma by the decrease of TBARS and increase of nonprotein thiols levels (CI-600). The histopathological analysis showed a significant decrease in the liver fat area for C. iguanaea extract compared to group C (p<0.001). Our results suggest that the biological effects of C. iguanaea extract could be related to the flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.