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Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l
- De Sabato, Luca, Lemey, Philippe, Vrancken, Bram, Bonfanti, Lebana, Ceglie, Letizia, Vaccari, Gabriele, Di Bartolo, Ilaria
- Virus research 2018 v.248 pp. 1-4
- Orthohepevirus A, phylogeny, feces, genotype, nucleotide sequences, sequence homology, swine
- The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.