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Novel starch based nano scale enteric coatings from soybean meal for colon-specific delivery

Sivapragasam, Nilushni, Thavarajah, Pushparajah, Ohm, Jae-Bom, Ohm, Jae-Bom, Margaret, Khaitsa, Thavarajah, Dil
Carbohydrate polymers 2014 v.111 pp. 273
Bifidobacterium, Lactobacillus brevis, Lactobacillus casei, acetic acid, butyrates, coatings, colon, digestion, drugs, enzymatic hydrolysis, fermentation, in vitro culture, microbial growth, nanoparticles, new methods, nutrients, pancreas, propionic acid, resistant starch, short chain fatty acids, solubility, soybean meal, stomach
Soybean meal was used to isolate resistant starch and produce nanoparticles, which could be potential coating materials for colonic nutrient and drug deliveries. The nanoparticles were in 40±33.2nm ranges. These nanoparticles were stable under simulated human physiological conditions. The degrees of dissolution in both stomach and intestinal conditions were less than 30%. Furthermore, the nanoparticles were less susceptible to pancreatic enzymatic digestion (20%), which was also evidenced by the co-existence of B-type crystalline pattern. In addition to the dissolution and digestion studies in the upper gastrointestinal tract, the nanoparticles were subjected to in vitro fermentation by Bifidobacterium brevis and Lactobacillus casei. Both species showed an increase in growth and activity, while producing short chain fatty acids: acetate, propionate, and butyrates in varying amounts. Overall this study clearly demonstrated a novel method that can be used for colon-specific delivery of bioactive compounds such as drugs and nutrients.