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Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

Author:
Maciejewska, Barbara, Olszak, Tomasz, Drulis-Kawa, Zuzanna
Source:
Applied microbiology and biotechnology 2018 v.102 no.6 pp. 2563-2581
ISSN:
0175-7598
Subject:
antibiotics, bacteria, bacterial infections, bacteriophages, enzymes, immune system, mechanism of action, phage therapy, pharmacokinetics, proteins
Abstract:
Bacteriophages (phages) are viruses that infect bacteria. The “predator–prey” interactions are recognized as a potentially effective way to treat infections. Phages, as well as phage-derived proteins, especially enzymes, are intensively studied to become future alternative or supportive antibacterials used alone or in combination with standard antibiotic regimens treatment. There are many publications presenting phage therapy aspects, and some papers focused separately on the application of phage-derived enzymes. In this review, we discuss advantages and limitations of both agents concerning their specificity, mode of action, structural issues, resistance development, pharmacokinetics, product preparation, and interactions with the immune system. Finally, we describe the current regulations for phage-based product application.
Agid:
5900508