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Preparation and Properties of Nanocolloidal Rhenium Sulfide Solution for Lymphoscintigraphic Methods of Micrometastase Examination

Author:
Manuilov, B.M., Ermakov, A.V.
Source:
Applied biochemistry and microbiology 2017 v.53 no.8 pp. 823-826
ISSN:
0003-6838
Subject:
aqueous solutions, desalination, diagnostic techniques, dialysis, gelatin, lymph nodes, neoplasms, neutralization, pH, patients, rhenium, sulfides, thiosulfates, ultrafiltration
Abstract:
A method for the preparation of a nanocolloidal solution of rhenium sulfide is proposed. It includes the following stages: interaction of ammonium perrhenate and sodium thiosulfate in an aqueous solution of gelatin in an acidic medium with heating to 70–80°C; neutralization to pH 7.0; dialysis against saline; desalination and concentrating by ultrafiltration. The resulting colloidal solution contains 85% of particles with an optimal size of 80–100 nm and can be used as a diagnostic tool for lymphoscintigraphy of sentinel lymph nodes in patients with cancer and other diseases.
Agid:
5901687