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Sesterterpenes and phenolic alkenes from the Thai sponge Hyrtios erectus

Author:
Kaweetripob, Wirongrong, Mahidol, Chulabhorn, Wongbundit, Siriporn, Tuntiwachwuttikul, Pittaya, Ruchirawat, Somsak, Prawat, Hunsa
Source:
Tetrahedron 2018 v.74 pp. 316-323
ISSN:
0040-4020
Subject:
Porifera, alkenes, cell lines, chemical reactions, chemical structure, cytotoxicity, neoplasms, spectral analysis
Abstract:
Sesterterpene, erectusolide A (1), six phenolic alkenes, erectuseneols A−F (2–7) and nine known compounds, luffalactone (8), luffariolide E (9), (6E)- and (6Z)-neomanoalide 24,25-diacetates (10 and 11), 6,6-dimethylundecane-2,5,10-trione (12), threo- and erythro-cavernosines (13 and 14), (4E,6E)-dehydromanoalide (15), echinoclerodane A (16), were isolated from the marine sponge Hyrtios erectus. Compound 13 was isolated for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The phenolic alkenes 3 and 7, the sesterterpenes 8–11 and 15, and compounds 12–14 were evaluated for cytotoxic activities against six cancer cell lines, MOLT-3, HepG2, HeLa, HuCCA-1, A549, and MDA-MB-231.
Agid:
5904624