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A self-delivery membrane system for enhanced anti-tumor therapy

Qiu, Wen-Xiu, Zhang, Ming-Kang, Liu, Li-Han, Gao, Fan, Zhang, Lu, Li, Shi-Ying, Xie, Bo-Ru, Zhang, Chi, Feng, Jun, Zhang, Xian-Zheng
Biomaterials 2018 v.161 pp. 81-94
antineoplastic activity, chimerism, focal adhesions, immune response, integrins, neoplasms, non-specific protein-tyrosine kinase, therapeutics
Nowadays, cell membrane targeting therapy has drawn much attention for its high anti-tumor effect by avoiding the cellular barriers. In this study, therapeutic agent conjugated chimeric peptide (Cp) was anchored in cracked cancer cell membranes (CCCM) to construct a self-delivery membrane system (M-Cp), which could relize precise cell membrane targeting therapy. It was found that compared with Cp, M-Cp could target to the cancer cell membrane with longer retention time, which is very crucial for in vivo applications. And the superior cell membrane targeting ability was attributed to the specific proteins (focal adhesion proteins, focal adhesion kinase, RHO family proteins, and integrin) on the CCCM surface. Importantly, the M-Cp could promote tumor-specific immune response, which further enhanced anti-tumor effect when combined with therapeutic agents in M-Cp. What's more, this self-delivery membrane system could be used as a template for cell membrane targeting therapy by changing the therapeutic agents as well as the CCCM, and this strategy would open a new window for various cell membrane targeting therapy.