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Triterpenoids from the leaves of Ilex chinensis
- Xia, Wen-Qi, Li, Ruo-Fei, Liu, Jia-Bao, Cui, Bao-Song, Hou, Qi, Sun, Hua, Li, Shuai
- Phytochemistry 2018 v.148 pp. 113-121
- Ilex, acetaminophen, hepatoprotective effect, human cell lines, in vitro studies, leaves, lipopolysaccharides, macrophages, mice, nitric oxide, spectral analysis, triterpenoid saponins
- Eleven previously undescribed compounds including two triterpenes, ilexchinenin A and ilexchinenin B, and nine triterpenoid saponins, ilexchinenosides A-I, along with twelve known triterpenoids were isolated from the leaves of Ilex chinensis Sims (Aquifoliaceae). Their structures were elucidated by spectroscopic analysis and comparison with known compounds. Furthermore, eight compounds exhibited significant inhibitory effects on NO production of lipopolysaccharide (LPS)-induced murine macrophages, while nine compounds exhibited potent hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays.