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Indole diterpenoids from the endophytic fungus Drechmeria sp. as natural antimicrobial agents

Zhao, Jian-Chao, Wang, Ya-Li, Zhang, Tian-Yuan, Chen, Zhong-Jian, Yang, Tian-Mei, Wu, Ying-Ying, Sun, Cheng-Peng, Ma, Xiao-Chi, Zhang, Yi-Xuan
Phytochemistry 2018 v.148 pp. 21-28
Bacillus cereus, Candida albicans, Klebsiella pneumoniae, Panax notoginseng, Pseudomonas aeruginosa, Staphylococcus aureus, anti-infective agents, antimicrobial properties, circular dichroism spectroscopy, culture media, diterpenoids, endophytes, fungi, molecular models, nuclear magnetic resonance spectroscopy, spectral analysis
A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng. Totally, seven new indole diterpenoids, drechmerins A-G (1–7), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8–11). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 μg/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds 1–3, 5–7, 9, and 10.