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Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
- Krstić, Gordana, Jadranin, Milka, Todorović, Nina M., Pešić, Milica, Stanković, Tijana, Aljančić, Ivana S., Tešević, Vele V.
- Phytochemistry 2018 v.148 pp. 104-112
- Euphorbia, P-glycoproteins, chemical structure, diterpenoids, latex, multiple drug resistance, neoplasm cells, neoplasms, nuclear magnetic resonance spectroscopy, spectral analysis, Serbia
- Seven previously undescribed jatrophane diterpenoids, nicaeenin A–G, with eight known jatrophane diterpenoids, namely euphodendrophanes A–C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments.All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.