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Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade)

Author:
Xiang, Limin, Wang, Yihai, Yi, Xiaomin, He, Xiangjiu
Source:
Phytochemistry 2018 v.148 pp. 87-96
ISSN:
0031-9422
Subject:
Solanum nigrum, acid hydrolysis, cell lines, glycosides, inhibitory concentration 50, lipopolysaccharides, neoplasms, nitric oxide, nuclear magnetic resonance spectroscopy, small fruits, spectral analysis, structure-activity relationships
Abstract:
Seven previously undescribed steroidal glycosides, along with three known congeners were isolated from the unripe berries of Solanum nigrum L. (Solanaceae). Their structures were elucidated on basis of 1D and 2D NMR, HR-ESI-MS spectroscopic data and GC analysis after acid hydrolysis. The potential inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 cell line and the anti-proliferative activities against five cancer cell lines (HL-60, U-937, Jurkat, K562 and HepG2) were evaluated. Seven compounds exhibited inhibition activities on NO production with IC50 values ranging from 11.33 to 49.35 μM. Structure-activity relationships of the isolated compounds were also discussed.
Agid:
5906705