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A facile strategy for achieving high selective Zn(II) fluorescence probe by regulating the solvent polarity

Wang, Haoping, Kang, Tiantian, Wang, Xiaoju, Feng, Liheng
Talanta 2018 v.184 pp. 7-14
acetonitrile, computer software, electrochemistry, fluorescent dyes, hydroxybenzaldehyde, metal ions, nuclear magnetic resonance spectroscopy, schiff bases, solvents, zinc
A simple Schiff base comprised of tris(2-aminoethyl)amine and salicylaldehyde was designed and synthesized by one-step reaction. Although this compound has poor selectivity for metal ions in acetonitrile, it shows high selectivity and sensitivity detection for Zn(II) ions through adjusting the solvent polarity (the volume ratio of CH3CN/H2O). In other words, this work provides a facile way to realize a transformation from poor to excellent feature for fluorescent probes. The bonding mode of this probe with Zn(II) ions was verified by 1H NMR and MS assays. The stoichiometric ratio of the probe with Zn(II) is 1:1 (mole), which matches with the Job-plot assay. The detection limitation of the probe for Zn(II) is up to 1 × 10−8 mol/L. The electrochemical property of the probe combined with Zn(II) was investigated by cyclic voltammetry method, and the result agreed with the theoretical calculation by the Gaussian 09 software. The probe for Zn(II) could be applied in practical samples and biological systems. The main contribution of this work lies in providing a very simple method to realize the selectivity transformation for poor selective probes. The providing way is a simple, easy and low-cost method for obtaining high selectively fluorescence probes.