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Tissue-Specific Antioxidative Responses and Cadmium Accumulation in Silurus meridionalis Under Chronic Waterborne Cadmium Exposure

Author:
Li, Jian, Yan, Yulian, Xie, Xiaojun
Source:
Bulletin of environmental contamination and toxicology 2018 v.100 no.4 pp. 485-491
ISSN:
0007-4861
Subject:
Silurus, antioxidant activity, antioxidants, cadmium, catalase, dose response, gills, glutathione, intestines, juveniles, kidneys, liver, malondialdehyde, superoxide dismutase, tissues
Abstract:
In this study, the oxidative damage, antioxidative responses and cadmium (Cd) accumulation in juvenile Silurus meridionalis were studied, after S. meridionalis were exposed to 0 (control), 62.5, 125, 250 and 500 µg Cd/L for 56 days. Cd accumulation, malondialdehyde, superoxide dismutase (SOD), catalase, glutathione (GSH) and total antioxidant capacity (T-AOC) were determined in gill, liver, kidney and intestine tissues. The results showed that the Cd accumulation in S. meridionalis was dose-dependent and tissue-specific, with the highest Cd content in the kidney, followed by the liver, gill, and intestine. Waterborne Cd stress in S. meridionalis was expressed as tissue-specific oxidative damage and antioxidant responses in gill, liver, kidney and intestine tissues. Waterborne Cd exposure induced the most significant oxidative damage in the gill, followed by the liver and kidney, while the intestine showed no sensitivity to waterborne Cd exposure. The antioxidants, such as SOD in the liver, kidney and intestine, as well as T-AOC and GSH in the gill, liver and kidney, were sensitive to waterborne Cd exposure.
Agid:
5908854