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Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling

Author:
Marshall, Fiona H.
Source:
Trends in biochemical sciences 2016 v.41 no.12 pp. 985-986
ISSN:
0968-0004
Subject:
G-protein coupled receptors, G-proteins, endosomes, multiprotein complexes, signal transducing adaptor proteins, signal transduction
Abstract:
A range of cutting-edge techniques have been employed to visualize ‘megaplexes’ consisting of a G protein-coupled receptor (GPCR) bound to β-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the heterotrimeric G protein, which retains full functional activity and supports sustained signaling from within the cell.
Agid:
5914699