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Uneven Braking Spins RNA Polymerase into a Pause

Author:
Artsimovitch, Irina, Belogurov, Georgiy A.
Source:
Molecular cell 2018 v.69 no.5 pp. 723-725
ISSN:
1097-2765
Subject:
DNA-directed RNA polymerase, RNA, nucleotides, transcription factors
Abstract:
In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.
Agid:
5914903