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Alchornoic acid derivatives from the fruits of Alchornea cordifolia (Schumach. & Thonn.) Muell. Arg. (Euphorbiaceae)

Author:
Ebessa, Virginie, Tiani, Gesquiere Laure M., Tchamgoue, Joseph, Kouam, Simeon F., Ngadjui, Bonaventure T., Green, Ivan R., Choudhary, Muhammad I., Tane, Pierre
Source:
Phytochemistry letters 2018 v.23 pp. 62-65
ISSN:
1874-3900
Subject:
Alchornea cordifolia, Citrobacter braakii, Escherichia coli, Klebsiella pneumoniae, fatty acids, fruits, gallic acid, medicinal plants, nuclear magnetic resonance spectroscopy, shikimic acid, spectral analysis, Cameroon
Abstract:
Two alchornoic acid derivatives, deepoxyalchornoic acid (1) and bisalchornoicester (2), together with six known compounds, alchornoic acid (3), gallic acid, 4-O-methylgallic acid, shikimic acid, kaempferol-3-O-galactoside and 2,3-dihydroxypropyl octacosanoate were isolated from a dichloromethane/methanol-soluble extract of the ripe fruits of the Cameroonian medicinal plant Alchornea cordifolia. The structures of the new fatty acid derivatives were elucidated by interpretation of their HRESIMS, 1D and 2D NMR spectroscopic data and by comparison with those reported in the literature. Some of the isolated compounds demonstrated inhibition activity against the microbial strains Escherichia coli, Klebsiella pneumoniae and Citrobacter braakii.
Agid:
5915515