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Paratrimerins G and H, two prenylated phenolic compounds from the stems of Paramignya trimera

Author:
Nguyen, Mai Thanh Thi, Dang, Phu Hoang, Nguyen, Tu Ngoc, Bui, Linh Thuy Thi, Nguyen, Hai Xuan, Le, Tho Huu, Van Do, Truong Nhat, Nguyen, Nhan Trung
Source:
Phytochemistry letters 2018 v.23 pp. 78-82
ISSN:
1874-3900
Subject:
Rutaceae, alpha-glucosidase, biochemical pathways, enzyme inhibition, inhibitory concentration 50, phenolic compounds, stems
Abstract:
From the stems of Paramignya trimera (Rutaceae), two new prenylated phenolic compounds, paratrimerins G (1) and H (2), together with 24 known compounds, as well as their α-glucosidase inhibitory activity was examined. Paratrimerins G (1) and H (2) showed moderate inhibitory effect, with the IC50 values of 89.2 and 58.8 μM, respectively. The plausible biosynthetic pathways of two new compounds was proposed.
Agid:
5915517