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Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity

Author:
Liu, Yushuang, Xue, Jingjing, Han, Jianxin, Hua, Huiming, Yuan, Tao
Source:
Phytochemistry letters 2018 v.23 pp. 168-171
ISSN:
1874-3900
Subject:
Carthamus tinctorius, circular dichroism spectroscopy, cytotoxicity, florets, fluorouracil, human cell lines, humans, inhibitory concentration 50, nuclear magnetic resonance spectroscopy, polyacetylenes, spectral analysis
Abstract:
Two new polyacetylenes, (2R,11S,12S)-(3E)-tridecene-5,7,9-triyne-1,2,11,12-tetraol (1) and (8S)-deca-4,6-diyne-1,8-diol-8-O-β-d-glucopyranoside (2), together with six known polyacetylenes (3–8), were isolated from the florets of Carthamus tinctorius. Their structures were elucidated on the basis of spectroscopic data (NMR and HRMS) and Mo2(OAc)4-induced circular dichroism. Compounds 4 and 5 were cytotoxic to the human cancer cell lines HL-60 (IC50 = 6.40, 3.66 μM), THP-1 (IC50 = 8.67, 6.69 μM) and PC-3 (IC50 = 11.30, 10.92 μM), comparable to the positive control, fluorouracil (IC50 = 2.58, 3.95 and 22.35 μM, respectively).
Agid:
5915521