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Atractylmacrols A-E, sesquiterpenes from the rhizomes of Atractylodes macrocephala
- Wang, Shuang-Yan, Ding, Lin-Fen, Su, Jia, Peng, Li-Yan, Song, Liu-Dong, Wu, Xing-De
- Phytochemistry letters 2018 v.23 pp. 127-131
- Atractylodes macrocephala, chemical constituents of plants, macrophages, nitric oxide, nuclear magnetic resonance spectroscopy, rhizomes, sesquiterpenoids, spectral analysis
- Phytochemical investigation of the rhizomes of Atractylodes macrocephala led to the isolation of five new sesquiterpenes, atractylmacrols A-E (1-5), as well as six known eudesmane sesquiterpenes (6-11). The structures of 1-5 were determined through interpretation of their 1D and 2D NMR spectroscopic data, as well as HREIMS values. Compounds 1-5 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW264.7 macrophages.