PubAg

Main content area

An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate

Author:
Jo, Minmi, Won, Sun-Woo, Lee, Dong Guk, Jung, Jae-Kyung, Kim, Sunhong, Kwak, Young-Shin
Source:
Archives of pharmacal research 2018 v.41 no.3 pp. 259-264
ISSN:
0253-6269
Subject:
amides, butyrates, carboxylic acids, chemical reactions, magnesium
Abstract:
Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB’s carboxylic acid using conventional amidation protocols is often problematic. We discovered that an amidation protocol utilizing methyl Boc-aminoisobutyrate and magnesium amidates of various reactivities produces the corresponding amide derivatives in good to excellent yields.
Agid:
5916643