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Characterization, anti-oxidation and anti-inflammation of polysaccharides by Hypsizygus marmoreus against LPS-induced toxicity on lung

Author:
Liu, Min, Li, Shangshang, Wang, Xiuxiu, Zhu, Yongfa, Zhang, Jianjun, Liu, Hui, Jia, Le
Source:
International journal of biological macromolecules 2018 v.111 pp. 121-128
ISSN:
0141-8130
Subject:
C-reactive protein, Hypsizygus marmoreus, antioxidant activity, antioxidants, blood serum, catalase, complement, enzyme activity, gamma-glutamyltransferase, glutathione peroxidase, histopathology, interleukin-1beta, lipid peroxidation, lipopolysaccharides, lungs, malondialdehyde, mice, mycelium, myeloperoxidase, protective effect, superoxide dismutase, toxicity, tumor necrosis factor-alpha
Abstract:
In our present work, the polysaccharides (MPS) were successfully extracted from the mycelia of Hypsizygus marmoreus, and purpose of our work was to evaluate the analysis of the characterization, anti-inflammation and anti-oxidation against the lung failure induced by lipopolysaccharide (LPS) in mice. Pretreatment with MPS at 800mg/kg markedly ameliorated the lung wet-to-dry weight (W/D) ratio and pulmonary histopathological conditions, reduced the tumor necrosis factor-alpha (TNF)-α, interleukin (IL)-6, and IL-1β levels in bronchoalveolar lavage fluid (BALF), myeloperoxidase (MPO) activities. In addition, the protective effects of MPS might be attributed to the down-regulations of the serum complement 3 (C3), glutamyl transpeptidase (GGT) and high-sensitivity C-reactive protein (hs-CPR) contents, as well as improving the antioxidant status by enhancing pulmonary enzyme activities (catalase (CAT), superoxide dismutase(SOD), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC)) and eliminating the lipid peroxidation (LPO) and malondialdehyde (MDA), respectively. What's more, our work investigated the characterization of the MPS.
Agid:
5917126