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Antioxidant activity of purified ulvan in hyperlipidemic mice

Author:
Li, Weida, Jiang, Nanfang, Li, Bingxi, Wan, Minghui, Chang, Xintao, Liu, Hui, Zhang, Li, Yin, Shupeng, Qi, Huimin, Liu, Shunmei
Source:
International journal of biological macromolecules 2018 v.113 pp. 971-975
ISSN:
0141-8130
Subject:
Ulva, algae, antioxidant activity, antioxidants, catalase, diet, glutathione peroxidase, hyperlipidemia, liver, malondialdehyde, mice, models, molecular weight, oxidative stress, sulfates, superoxide dismutase, uronic acids
Abstract:
Several studies have reported that ulvan from the alga Ulva pertusa (Chlorophyta) exhibits substantial antioxidant and antihyperlipidemic activities; however, which group of heteropolysaccharides play roles in these activities remains unknown. In this study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAE-Sepharose fast-flow column. The antioxidant activity was detected via the model of hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3, which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%) as well as the lowest average molecular weight (83,094 Da), exhibited the stronger antioxidant activity than other examples. It significantly decreased MDA (29.2%; P < 0.05), increased SOD (36.4%; P < 0.05) and CAT (43.6%; P < 0.05) compared with hyperlipidemia group. In conclusion, PU3 may be potential sources of natural antioxidant to protecting against the liver damage of oxidative stress induced by cholesterol-rich diet.
Agid:
5917138