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Antioxidant activity of purified ulvan in hyperlipidemic mice

Li, Weida, Jiang, Nanfang, Li, Bingxi, Wan, Minghui, Chang, Xintao, Liu, Hui, Zhang, Li, Yin, Shupeng, Qi, Huimin, Liu, Shunmei
International journal of biological macromolecules 2018 v.113 pp. 971-975
Ulva, algae, antioxidant activity, antioxidants, catalase, diet, glutathione peroxidase, hyperlipidemia, liver, malondialdehyde, mice, models, molecular weight, oxidative stress, sulfates, superoxide dismutase, uronic acids
Several studies have reported that ulvan from the alga Ulva pertusa (Chlorophyta) exhibits substantial antioxidant and antihyperlipidemic activities; however, which group of heteropolysaccharides play roles in these activities remains unknown. In this study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAE-Sepharose fast-flow column. The antioxidant activity was detected via the model of hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3, which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%) as well as the lowest average molecular weight (83,094 Da), exhibited the stronger antioxidant activity than other examples. It significantly decreased MDA (29.2%; P < 0.05), increased SOD (36.4%; P < 0.05) and CAT (43.6%; P < 0.05) compared with hyperlipidemia group. In conclusion, PU3 may be potential sources of natural antioxidant to protecting against the liver damage of oxidative stress induced by cholesterol-rich diet.