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Cu-catalyzed direct C-H thiolation of electron-rich arenes with arylsulfonyl hydrazides

Author:
Chen, Lingjuan, Liu, Ping, Wu, Jianglong, Dai, Bin
Source:
Tetrahedron 2018 v.74 pp. 1513-1519
ISSN:
0040-4020
Subject:
aromatic hydrocarbons, chemical reactions, chemical structure, hydrazides
Abstract:
An efficient Cu-catalyzed direct C–H thiolation of electron-rich arenes with arylsulfonyl hydrazides has been developed. Various mono(or bis)-thioether products were obtained in moderate to good yields. Mechanistic studies suggest that the reaction likely proceeds through free-radical formation including arylthio radical and sulfonyl radical, while both disulfanes and sulfonothioates are the major thiolation species in this transformation.
Agid:
5922405