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Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy

Wu, Bo, Lu, Shu-Ting, Yu, Hui, Liao, Ru-Fang, Li, Huan, Lucie Zafitatsimo, B.V., Li, Yu-Shuang, Zhang, Ying, Zhu, Xiao-Lei, Liu, Hong-Guang, Xu, Hai-Bo, Huang, Shi-Wen, Cheng, Zhen
Biomaterials 2018 v.159 pp. 37-47
X-radiation, biocompatibility, biosafety, bismuth, image analysis, in vivo studies, magnetic resonance imaging, nanoparticles, neoplasms, therapeutics
Multifunctional nanomaterials with simple structure and good biosafety, integrating multimodal imaging and therapeutic functions, can facilitate the development of clinical cancer treatments. Here, a simple but powerful pure bismuth based nanoparticle (Gd-PEG-Bi NPs) was developed from pure Bi NPs and gadolinium-diethylenetriaminepentaacetic acid-bis-tetradecylamide, which not only shows high quality MRI/CT/PAI triple-modal imaging, but can also be a potent photothermal therapy agent under the guidance of the triple-modal imaging. The Gd-PEG-Bi NPs showed good stability and excellent biocompatibility. In vitro and in vivo study demonstrated that Gd-PEG-Bi NPs have ultrahigh X-ray attenuation coefficient, short T1 relaxation time in MRI, and strong PAI signal. Following the imaging diagnosis, the excellent light-to-heat conversion efficiency of Gd-PEG-Bi NPs was capable of suppressing the tumor growth effectively under near-infrared laser radiation in vivo. Such multifunctional nanoparticles were ideal candidates for cancer diagnosis and treatment.