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Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy
- Wu, Bo, Lu, Shu-Ting, Yu, Hui, Liao, Ru-Fang, Li, Huan, Lucie Zafitatsimo, B.V., Li, Yu-Shuang, Zhang, Ying, Zhu, Xiao-Lei, Liu, Hong-Guang, Xu, Hai-Bo, Huang, Shi-Wen, Cheng, Zhen
- Biomaterials 2018 v.159 pp. 37-47
- X-radiation, biocompatibility, biosafety, bismuth, image analysis, in vivo studies, magnetic resonance imaging, nanoparticles, neoplasms, therapeutics
- Multifunctional nanomaterials with simple structure and good biosafety, integrating multimodal imaging and therapeutic functions, can facilitate the development of clinical cancer treatments. Here, a simple but powerful pure bismuth based nanoparticle (Gd-PEG-Bi NPs) was developed from pure Bi NPs and gadolinium-diethylenetriaminepentaacetic acid-bis-tetradecylamide, which not only shows high quality MRI/CT/PAI triple-modal imaging, but can also be a potent photothermal therapy agent under the guidance of the triple-modal imaging. The Gd-PEG-Bi NPs showed good stability and excellent biocompatibility. In vitro and in vivo study demonstrated that Gd-PEG-Bi NPs have ultrahigh X-ray attenuation coefficient, short T1 relaxation time in MRI, and strong PAI signal. Following the imaging diagnosis, the excellent light-to-heat conversion efficiency of Gd-PEG-Bi NPs was capable of suppressing the tumor growth effectively under near-infrared laser radiation in vivo. Such multifunctional nanoparticles were ideal candidates for cancer diagnosis and treatment.