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Cardioprotective effect of cerium oxide nanoparticles in monocrotaline rat model of pulmonary hypertension: A possible implication of endothelin-1

Nassar, Seham Zakaria, Hassaan, Passainte S., Abdelmonsif, Doaa A., ElAchy, Samar Nabil
Life sciences 2018 v.201 pp. 89-101
albino, animal models, antioxidant activity, antioxidants, blood serum, cardioprotective effect, ceric oxide, endothelins, hypertension, hypertrophy, lung function, monocrotaline, nanoparticles, oxidative stress, rats, spironolactone, subcutaneous injection, therapeutics
Cerium oxide nanoparticles (CeO2NPs) have been recently introduced into the medical field for their antioxidant properties. The ability of CeO2NPs alone or in combination with spironolactone (SP) to attenuate monocrotaline (MCT)-induced pulmonary hypertension and associated right ventricular hypertrophy was studied in rats. A special emphasis was given to endothelin-1 pathway.Pulmonary hypertension was induced in albino rats by a single subcutaneous injection of MCT (60 mg/kg). Rats received either single CeO2NPs therapy or combined therapy with SP for 2 weeks.CeO2NPs improved pulmonary function tests with concomitant decrease in serum endothelin-1 and pulmonary expression of endothelin-1 and its receptor ETAR. Besides, CeO2NPs diminished MCT-induced right ventricular hypertrophy and reduced cardiac oxidative stress and apoptosis.CeO2NPs could improve pulmonary hypertension and associated right ventricular hypertrophy with no additive value for SP. Besides being an antioxidant, CeO2NPs work through endothelin-1 pathway to improve pulmonary hypertension.