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Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid
- Zhang, Yiliang, He, Li, Shi, Lei
- Tetrahedron letters 2018 v.59 no.16 pp. 1592-1595
- chemical reactions, chemical structure, hydrogen, organic compounds, phosphoric acid
- The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities.