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Genetic analysis of rotavirus G2P strains in Pune, Western India: circulation of a novel reassortant bearing E6 NSP4 genotype
- Pradhan, GauriN., Chitambar, ShobhaD.
- Archives of virology 2018 v.163 no.5 pp. 1391-1394
- Rotavirus A, children, gastroenteritis, genes, genetic analysis, genotype, phylogeny, India
- In India, G2P strains are known to be the second most predominant group A rotaviruses causing acute gastroenteritis among children. This study was performed to determine the diversity within VP7(G), VP4(P), VP6(I) and NSP4(E) genes of 16 G2P rotavirus strains detected in children hospitalized for acute gastroenteritis in Pune, Western India during 2009-2013. Fourteen strains showed G2-P-I2-E2 and two strains showed G2-P-I2-E6 genotype constellation. Phylogenetic analysis showed their clustering into G2-IV-a3, P-5bi/ii, I2-3ii and E2-4i/ii or E6 genotypes/lineages. These data reveal inter- and/or intra-genotypic variations in a genogroup-2 constellation of G2P rotavirus strains circulating in Pune, Western India, providing evidence of a novel G2P reassortant bearing a rare NSP4 genotype, E6 during 2009-2013.