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New S-Monoterpenylcysteines

Author:
Melekhin, A.K., Sudarikov, D.V., Shevchenko, O.G., Rubtsova, S.A., Kuchin, A.V.
Source:
Chemistry of natural compounds 2018 v.54 no.2 pp. 281-285
ISSN:
0009-3130
Subject:
antioxidant activity, cytotoxicity, erythrocytes, hemolysis, mice, models, serine, sulfides
Abstract:
New sulfides based on 4-caranethiol, 3-hydroxyisocaranethiol, neomenthanethiol, 10-thioisoborneol, 10-hydroxyisocamphenylthiol, and 10-thioisocampheol containing L-serine residues were synthesized for the first time in 40–70% yields. The synthesized compounds were not cytotoxic in a laboratory mouse erythrocyte hemolysis model and possessed statistically significant membrane-protective and antioxidant activity at a concentration of 50 μmol/L.
Agid:
5932106