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Tuning Biased GPCR Signaling for Physiological Gain

Author:
Spangler, Skylar, Bruchas, Michael R.
Source:
Cell 2017 v.171 pp. 989-991
ISSN:
0092-8674
Subject:
G-protein coupled receptors, adverse effects, animals, ligands, morphine, quantitative analysis, therapeutics
Abstract:
Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.
Agid:
5933824