Jump to Main Content
Tuning Biased GPCR Signaling for Physiological Gain
- Spangler, Skylar, Bruchas, Michael R.
- Cell 2017 v.171 pp. 989-991
- G-protein coupled receptors, adverse effects, animals, ligands, morphine, quantitative analysis, therapeutics
- Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.